Roberto Prosseda has performed regularly with some of the world’s most important orchestras, such as the London Philharmonic Orchestra, New Japan Philharmonic, Moscow State Philharmonic, Bruxelles Philharmonic, Calgary Philharmonic, Saatskapelle Weimar, Sinfonia Lahti, Berliner Symphoniker, Santa Cecilia, Filarmonica della Scala, Leipzig Gewandhaus. He played under the baton of David Afkham, Marc Albrecht, Christian Arming, Harry Bickett, Oleg Caetani, Riccardo Chailly, Pietari Inkinen, Yannik Nezeit-Seguin, George Pehlivanian, Dennis Russel-Davies, Tugan Sokhiev, Jurai Valcuha, Jan Willem de Vriend. With the Gewandhaus Orchestra, conducted by Riccardo Chailly, he recorded live the 3rd Piano Concerto in E minor by Mendelssohn, released on the Decca International label in September 2009.
Other than Mendelssohn, of whose piano music he is considered to be one of today's leading interpreters, Prosseda’s performances of Mozart, Schubert, Schumann and Chopin have been particularly praised, and these composers have in fact featured in Prosseda’s recent Decca recordings, including the complete Mozart Sonatas (2015-18). An active proponent of Italian music, Prosseda also recorded the complete piano works of Petrassi and Dallapiccola.
In September 2011 Prosseda gave his debut on the pedal piano, performing the Concerto for Pedal Piano by Gounod in the world premiere in modern times. He has given more than 50 concerts with the pedal piano, rediscovering the original compositions by Robert Schumann, Franz Liszt and Charles Valentin Alkan. Several composers, including Ennio Morricone, have already written new pieces for pedal piano for Roberto Prosseda, and a recording of Gounod's four pieces for pedal piano and orchestra with the Orchestra della Svizzera Italiana conducted by Howard Shelley was released on the Hyperion label in 2013.
Roberto Prosseda is also very active in musical divulgation. He wrote the book “Il Pianoforte” for Edizioni Curci (2013) and made three documentaries dedicated to Mendelssohn, Chopin and Liszt (Euroarts).